Organ transplant recipients must continue immunosuppressive therapy throughout their lives, and adherence to these medications is critical for long-term graft survival. Multiple factors influence adherence, including socioeconomic status,
treatment-related variables, patient characteristics, disease-related factors, and components associated with the healthcare system and team. Addressing these multifactorial challenges requires the integration of educational, cognitive, behavioral, psychological, and emotional strategies. As integral members of the multidisciplinary healthcare team, nurses play a central role in identifying barriers to adherence, utilizing appropriate assessment tools, and implementing evidence-based, patient-centered interventions. This review highlights nurses’ responsibilities and contributions in promoting adherence and supporting transplant recipients throughout their post-transplant journey.